Lethal bird flu is now spreading in Australia. This is bad news for many native species.

New federal government analysis suggests close to one in five Australian bird and mammal species is at high, very high or extreme risk. But this risk assessment omits something vital – how genetically well-equipped the species is to fight the virus.

While species such as black swans are likely to be very hard-hit, others such as wild ducks are expected to be less affected. One reason for this is different immune systems – some are more or less able to fight the virus. But there’s a more significant factor – how much variation there is in key immune system genes across populations.

Right now, we don’t have an overview of which threatened species are at highest risk based on this. If we urgently create a national immune-risk map for species at risk, we can act to protect those in most danger.

Why immune gene variations matter

When a virus enters an animal’s body, its immune system must first detect it, then respond. Key immune genes help determine if an animal fights off infection, becomes seriously ill or dies.

Different individuals will have slightly different immune responses based on variations at different immune genes. Some variants will allow an individual to survive the virus, and others won’t. This is why diversity in these genes is critical across the........

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