$12 billion AI startup founder says future tech giants could operate with fewer than 100 employees

Good morning. Could the next generation of tech giants fit in a single office?

In the coming years, some of the most valuable companies in the world will have “sub-100 employees,” Daniel Nadler, the founder and CEO of OpenEvidence, predicted during a panel session at Nvidia’s GTC 2026 summit on Monday. “I think the world’s not prepared for that,” Nadler said.

OpenEvidence is an AI‑powered medical information and clinical decision support company used by physicians. In January, the startup closed a $250 million Series  D funding round, co‑led by Thrive Capital and DST Global, which doubled its valuation to approximately $12  billion.

“Take OpenEvidence, we have sub-100 employees, yet 300 million Americans will be treated this year by a doctor who used OpenEvidence in the loop,” Nadler said. Each employee in his company is indirectly supporting millions of patients, he said.

“The scale is unfathomable, and that’s directly a result of what Jensen and Nvidia, and these tools and the people who develop on top of that technology have enabled as the new starting point,” he said, adding, “I think the world economy—and certainly the tech economy—is going to look unrecognizable.”

Leaders across tech are beginning to echo the idea that companies could be built and run by smaller teams. For example, OpenAI CEO Sam Altman has emphasized that AI acts as a collaborator that lets individuals and small teams achieve results that once required much larger organizations, amplifying productivity and creativity. Block recently announced it would cut 40% of the fintech company’s headcount........

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