For some people, depression is like an unwanted guest who moves in and refuses to leave. Even with therapy and medication, the heavy fog of low mood, exhaustion and hopelessness never fully lifts for long. For around 30% of people with depression, this is a daily reality.

It’s not just a personal burden. Difficult-to-treat depression affects families, workplaces and communities – and carries a huge cost for society.

In England, the NHS Talking Therapies programme is the first place many adults turn when they’re struggling with depression or anxiety. In 2023-24, it supported more than 1.26 million people. Yet, for all its reach, around half of those who complete treatment still feel depressed........

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