Cannabis products are getting more potent and easier to buy around the world. Yet little is known about how bigger doses of tetrahydrocannabinol (THC), the main active ingredient in cannabis, change what people feel. Our new research found that larger doses generally make people feel more high, but not in a straight line. Doubling the dose does not double the feeling of intoxication.

This leaves a simple but important question for first-time and returning users: how will the amount of THC I take make me feel?

Cannabis laws have changed in many countries, and in some cases this has led to increased access to and diversity of products, as well as some increases in first-time cannabis users. Meanwhile, the amount of THC in cannabis products has been rising around the world, whether or not cannabis is legal.

THC is the part of cannabis that changes how you think and feel, and it produces both positive and negative effects. It does this by acting on receptors in the brain, mainly one called CB1. These receptors are part of the endocannabinoid system, which helps keep the body stable and protected.

First-time and inexperienced users are the most........

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