What Contributes to Appetite?

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The use of GLP-1 and GIP weight-loss drugs has revealed the profound affect of food noise.

Research into those drugs has pointed to complex food noise mechanisms.

Information about food noise could benefit many who struggle with their weight.

The advent of the GLP-1 and GIP agonist drugs has brought along with it an increased focus on “food noise.” Many people on one or both of those medications report a serious reduction in food noise, which has been defined as “intrusive and often unwanted thoughts about food.” As more and more research has emerged, reduction of food noise has been identified as a major key to the weight loss seen with these drugs, and to weight loss in general.

In people with type 2 diabetes, the GLP-1s and GIPs (known as incretin hormones) have been shown to improve glycemic control and reduce plasma glucose. As it turns out, both type 2 diabetics and people with obesity show impaired GLP-1 secretion in the gut. Both groups taking the supplemental incretin hormones show a reduction in food intake and appetite.

GLP-1 and GIP supplements have a wide distribution in many areas of the brain as well, thanks to their ability to cross the blood-brain barrier via the paraventricular organs. Most notably, they can affect the hypothalamus, which is like an orchestra leader for many feedback mechanisms related to appetite and appetite control. For example, introducing incretin hormones to the hypothalamus has........

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