Iran and the United States prepared for a fifth round of negotiations over Tehran’s rapidly advancing nuclear program Friday in Rome, with enrichment emerging as the key issue.

U.S. officials up to President Donald Trump insist Iran cannot continue to enrich uranium at all in any deal that could see sanctions lifted on Tehran’s struggling economy. Iran’s Foreign Minister Abbas Araghchi early Friday insisted online that no enrichment would mean “we do NOT have a deal.”

“Figuring out the path to a deal is not rocket science,” Araghchi wrote on the social platform X. “Time to decide.”

The U.S. will be again represented in the talks by Mideast envoy Steve Witkoff and Michael Anton, the State Department’s policy planning director. Oman’s Foreign Minister Badr al-Busaidi is mediating the negotiations as the sultanate on the Arabian Peninsula has been a trusted interlocutor by both Tehran and Washington in the talks.

A car carrying Araghchi arrived at the Omani Embassy in Rome’s Camilluccia neighborhood around 12:30 p.m. Witkoff had yet to be seen, but the embassy previously served as the site of another round of talks.

The talks seek to limit Iran’s nuclear program in........

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