New drug combo may preserve muscle during weight loss

(NewsNation) — A recent trial suggests apitegromab, when used alongside tirzepatide, may help preserve lean body mass while supporting overall weight loss.

The analysis, published in Nature, found apitegromab — a monoclonal antibody — targets myostatin to help maintain muscle mass when combined with the GLP-1 medication. Apitegromab works by inhibiting the activation of myostatin, a protein that limits skeletal muscle growth, according to Medscape.

“Results from EMBRAZE demonstrate clinical proof of concept for a highly selective anti-myostatin antibody to preserve........

© The Hill