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Only 1/3 of depression patients achieve remission with traditional antidepressants.

In a Brazilian study, 77% of treatment-resistant patients improved with just 10mg of sublingual ketamine.

Low-dose sublingual ketamine is affordable, home-based, and is often more effective long-term than IV ketamine

Dr. Rachel Wilkenson pioneered a low-dose protocol used to treat hundreds of patients with remarkable results.

After practicing psychiatry for almost 40 years, I was starting to feel like I had seen and heard it all. Thousands of patients had come to my office seeking relief from depression, anxiety and related disorders, and many of them improved with conventional treatments that include psychiatric medications and psychotherapy. Some even improved to a point where they were no longer depressed, or their anxiety was manageable.

Statistics show that about one-third of people with depression achieve remission—meaning their symptoms are gone—with traditional antidepressant medications. This matched my experience treating people, and I had grown to accept that this was as good as it gets. Although I wasn’t thrilled with the fact that many people continued to struggle with significant symptoms of persistent depression, it seemed this was as good as we could do. The scientific literature demonstrates that about one-third of depressed patients achieve remission, one-third show some improvement, and one-third don't respond at all.

And then, about three and a half years ago, something remarkable happened.

A Study That Seemed Too Good to Be True

While reading through studies describing novel treatments for depression, I stumbled upon an article written by a group of doctors from Brazil describing results that seemed too good to be true. Diogo Lara and his colleagues administered a very low dose of ketamine—just 10 mg under the tongue (sublingual)—to 26 patients who suffered from treatment-refractory depression or bipolar disorder. The patients took this medicine every two to seven days. These were people who had previously failed to respond to at least four medications that were routinely used........

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