Three years ago, Daniel Nadler launched OpenEvidence, an AI-based search tool that helps doctors get answers to complicated clinical questions quickly and easily. Now, the startup’s latest $250 million fundraise, which doubled its valuation to $12 billion, has made Nadler twice as rich. Forbes estimates that the Miami-based AI founder is now worth $7.6 billion, up more than 100% from his $3.6 billion net worth in late October.

OpenEvidence has quickly become one of the hottest AI startups in the healthcare sector. Today some 740,000 physicians — about 45% of doctors in the United States — use the search engine to scan through millions of peer-reviewed research publications across top medical journals and find useful (sometimes lifesaving) information in seconds instead of hours or days. Last month, physicians turned to the software in some 18 million clinical consultations, Nadler said. “We've become the default operating system for doctors,” he told Forbes.

The startup crossed $100 million in annualized run rate in 2025, making money from advertising........

© Forbes