U.S. officials fear regime change. They dread instability and the unknown. In reality, naysayers are seldom right. Post-World War II Germany and Japan show that regime change can work. The problem in Afghanistan and Iraq was less regime change than misguided nation-building and wishful blindness to Iranian and Pakistani interference. Regardless, today, Iraq is not the failed state many Americans assume; it has a booming economy and youthful energy, even if it has a Wild West-meets-1930s Chicago vibe. The verdict is not yet in on Syria as Ahmad al-Sharaa’s sectarian vigilantism and his family’s monopolization of the economy suggest he is little more than a Sunni version of Bashar Assad.

Some regime change is inevitable. Even prior to the 12-day Israel-Iran war, the Islamic Republic’s Supreme Leader, Ali Khamenei, 86, is in poor health as he has had cancer and is partially paralyzed. Iranians were openly........

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