The Isaac Accords are opening new avenues for diplomatic engagement as a wave of Latin American leaders breaks from past alignments hostile to the West.

Colombia’s president, Gustavo Petro, was on brand when he recently posted “Heil Hitler” in response to an article he disagreed with and, days later at the UN Security Council, compared Israel to Nazi Germany. Long before he severed relations with Israel over the Gaza war, Petro had made similar comparisons. He was hardly alone. For years, far-left Latin American leaders have treated hostility toward Israel as both an ideological reflex and shorthand for opposition to the West. Yet as Petro nears the end of his presidency, the politics he represents may be giving way to a new era across Latin America.

The Isaac Accords point toward that future.

The initiative’s name evokes the Abraham Accords, agreements that normalized relations between Israel and several Arab and Muslim-majority states beginning in 2020. Those relationships have weathered the Gaza war and Israel’s confrontation with Iran. The Isaac Accords aim to emulate that success in Latin America.

Argentina’s President Javier Milei and Israeli Prime Minister Benjamin Netanyahu signed the Isaac Accords in April, less than a year after the initiative was........

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