Mirror life is a scientific fantasy leading to a dangerous reality − a synthetic biologist explains how mirror bacteria could conquer life on Earth
Most major biological molecules, including all proteins, DNA and RNA, point in one direction or another. In other words, they are chiral, or handed. Like how your left glove fits only your left hand and your right glove your right hand, chiral molecules can interact only with other molecules of compatible handedness.
Two chiralities are possible: left and right, formally called L for the Latin laevus and D for dexter. All life on Earth uses L proteins and D sugars. Even Archaea, a large group of microorganisms with unusual chemical compositions, stick to the program on the handedness of the main molecules they use.
For a long time, scientists have been speculating about making biopolymers that would mirror compounds in nature but in the opposite orientation – namely, compounds made of D proteins and L sugars. Recent years have seen some promising advancements, including enzymes that can make mirror RNAs and mirror DNAs.
When scientists observed that these mirror molecules behave just like their natural equivalents they considered that it would be possible to make a whole living cell from them. Mirror bacteria in particular had the potential to be a useful basic research tool – possibly allowing scientists to study a new tree of life for the first time and solve many problems in bioengineering and biomedicine.
This so-called mirror life – living cells made from building blocks with an opposite chirality to those that make up natural life – could have very similar properties to natural living cells. They could live in the same environment, compete for resources and behave like you would expect of any living organism. They would be able to evade infection from other predators and immune systems because these opponents wouldn’t be able to........
© The Conversation
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