World leaders urged restraint on Friday after Israel pounded Iran, striking 100 targets including nuclear and military sites, and killing senior figures.

Here is a roundup of key reactions:

"There has already been great death and destruction, but there is still time to make this slaughter, with the next already planned attacks being even more brutal, come to an end," US President Donald Trump said on his Truth Social platform, adding that Israel has a lot of weapons thanks to the United States and "they know how to use it".

Earlier in the day, Trump told Fox News that "Iran cannot have a nuclear bomb and we are hoping to get back to the negotiating table."

UN chief Antonio Guterres asked "both sides to show maximum restraint, avoiding at all costs a descent into deeper conflict, a situation that the region can hardly afford," according to a spokesperson.

Guterres was "particularly concerned" by Israel's strikes on nuclear installations amid the ongoing US-Iran negotiations.

"Russia is concerned and condemns the sharp escalation of tensions," spokesman Dmitry Peskov told state news agencies, calling the strikes........

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