Top diplomat on Middle Eastern regime change as a losing game: ‘U.S. history in that area of the world is not good with this’

After the largest buildup of U.S. warships and aircraft in the Middle East in decades, American and Israeli military forces launched a massive assault on Iran on Feb. 28, 2026.

President Donald Trump has called the attacks “major combat operations” and has urged regime change in Tehran. Iranian media reported Supreme Leader Ayatollah Ali Khamenei was killed in the strikes.

To better understand what this means for the U.S. and Iran, Alfonso Serrano, a U.S. politics editor at The Conversation, interviewed Donald Heflin, a veteran diplomat who now teaches at Tufts University’s Fletcher School.

Widespread attacks have been reported across Iran, following weeks of U.S. military buildup in the region. What does the scale of the attacks tell you?

I think that Trump and his administration are going for regime change with these massive strikes and with all the ships and some troops in the area. I think there will probably be a couple more days’ worth of strikes. They’ll start off with the time-honored strategy of attacking what’s known as command and control, the nerve centers for controlling Iran’s military. From media reporting, we already know that the residence of Khamenei was attacked.

What is the U.S. strategic end game here?

Regime change is going to be difficult. We heard Trump today call for the Iranian people to bring the government down. In the first place, that’s difficult. It’s hard for people with no arms in their hands to bring down a very tightly controlled regime that has a lot of arms.

The second point is that U.S. history in that area of the world is not good with this. You may recall that during the Gulf War of 1990-1991, the U.S. basically encouraged the Iraqi people to rise up, and then made its own decision not to attack Baghdad, to stop short. And that has not been forgotten........

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