‘It was like a godsend’ —GLP-1 drugs show promise against hormonal disorder that causes constant weight gain and forces women to shave facial hair

Charlotte Touzalin was still a young teenager when she began struggling with weight gain, abnormal periods and unwanted facial hair — the same puzzling symptoms that plagued her mom for decades and that no doctor could piece together.

“I’d go home and I’d cry,” said Touzalin, an 18-year-old college student from Colorado. “I didn’t understand why all this weight was coming back or why my friends didn’t have to shave their faces and I had to.”

Touzalin and her mom, Anne Schultz, were finally diagnosed with polyendocrine metabolic ovarian syndrome, a hormonal condition affecting 1 in 8 women worldwide. But unlike her mom, Touzalin is beginning young adulthood with new hope after taking part in a study testing blockbuster GLP-1 drugs as a treatment.

A small but growing body of research shows that these obesity medications may also work for the disorder known as PMOS — not only by promoting weight loss but also by improving insulin resistance, hormone balance and ovulation. These things are key to the disease, which used to be called polycystic ovary syndrome but was renamed earlier this year to shift the focus away from ovaries and cysts.

“We need to do a better job taking care of it,” said Dr. Melanie Cree, who has led three studies testing GLP-1 drugs for PMOS including the one Touzalin joined. “We are finding them incredibly effective and really exciting for improving symptoms in women with this condition.”

PMOS is a mysterious and maddening disease

Touzalin and her mom’s long, frustrating journey with PMOS is common.

Diagnosis often takes years........

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