How a simple blood test could help detect heart damage during breast cancer treatment
Modern breast cancer screening and treatment have transformed survival. Many women now live long and healthy lives after diagnosis, thanks to increasingly effective chemotherapy and targeted therapies: medicines designed to attack particular features of cancer cells.
But as cancer outcomes improve, another challenge has become more apparent: protecting the heart from the side-effects of treatment.
Some breast cancer treatments can affect heart health. These include anthracyclines, a group of chemotherapy drugs, and trastuzumab, a targeted therapy used to treat HER2-positive breast cancers: cancers that have high levels of HER2, a protein that helps cells grow and divide.
In some patients, these treatments can weaken the heart’s ability to pump blood around the body or contribute to heart failure. Other cancer treatments can increase the risk of abnormal heart rhythms.
Early changes may not cause obvious symptoms. By the time a patient experiences breathlessness, fatigue or palpitations, the sensation that the heart is pounding or beating irregularly, damage may already have occurred.
A small study, which is yet to be peer reviewed, suggests that regular blood tests and heart traces could help doctors detect warning signs earlier.
Researchers followed 50 women with stage 1 to 3 breast cancer, cancer that had not spread to distant organs, through six cycles of........
