The joint US–Israel strikes on Iran, which killed the Iranian supreme leader, Ayatollah Ali Khamenei, and Tehran’s retaliatory strikes on Israel and neighbouring Arab countries have again plunged the Middle East into war.

US President Donald Trump and Israeli Prime Minister Benjamin Netanyahu said their aim is to bring about a favourable regime change in Iran. The implications of this for Iran, the region and beyond should not be underestimated.

Although Khamenei’s killing is a significant blow to the Islamic regime, it is not insurmountable. Many Iranian leaders have been killed in the past, including Qassem Soleimani, Tehran’s regional security architect, who was assassinated by the US in January 2020.

But they have been replaced relatively smoothly, and the Islamic regime has endured.

Khamenei’s departure is unlikely to mean the end of the Islamic regime in the short run. He anticipated this eventuality, and reportedly last week arranged a line of succession for his leadership and that of senior military, security and political leaders if they were “martyred”.

However, Khamenei was both a political and spiritual leader. He has commanded followers not only among devout Shias in Iran, but also many Muslims across the wider region. His assassination will spur some of them to seek revenge, potentially sparking a wave of extremist violent actions in the region and beyond.

A regime built for survival

Under a constitutional provision of the Islamic Republic, the Assembly........

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