Humphry Slocombe and Señor Sisig collaborated on an ice cream flavor called Churron.

One of San Francisco’s most popular ice cream businesses is set to close its flagship store in the Mission.

Humphry Slocombe, a pioneering scoop shop famous for inventive flavors like the boozy Secret Breakfast made with real bourbon, announced that its original location at 2790 Harrison St. is slated to close Oct. 30. The news was first reported by the San Francisco Chronicle. (The Chronicle and SFGATE are both owned by Hearst but have separate newsrooms.)

“Throughout COVID, we were able to keep all of our shops open thanks to the loyalty and support of all of you,” read an Instagram post by Humphry Slocombe. “We were especially proud of keeping our original shop at the Mission open to........

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